Further, a retrospective study with large patient population including 1,007 prostate cancer patients have shown an overall detection rate of 79.5% along with the sensitivities of 46, 46, and 73% for PSA levels of 0.2 ng/mL or less, 0.21 to 0.5 ng/mL, and 0.51 to 1.0 ng/mL, respectively.22, 25, 26The results of this study are in accordance with those of previous studies indicating an overall detection rate of 78.9% along with the sensitivities of 75.0, 20.0, 50.0, 88.90, and 89.3% in the patients with PSA ≤ 0.2, 0.2 < PSA ≤ 1, 1 < PSA ≤ 3, 3 < PSA ≤ 10, and PSA > 10, respectively. The gene discussed is KLK3; the disease is Familial prostate cancer.