Based on the results of Figure 5C and Supplementary Table 2, we found that the differential metabolites were significantly enriched in the pathways of “mTOR signaling pathway,” “central carbon metabolism in cancer,” “valine, leucine and isoleucine biosynthesis,” “insulin signaling pathway,” “glucagon signaling pathway,” “sphingolipid signaling pathway,” “FoxO signaling pathway,” “Citrate cycle (TCA cycle),” “AMPK signaling pathway,” “HIF-1 signaling pathway” and “cGMP-PKG signaling pathway.” The gene discussed is INS; the disease is cancer.