p-Mentha-1,3,8-triene and perilla alcohol are upregulated in the ALAEm group and are generally found in essential oils with antimicrobial and antioxidant activities (94, 99), which reduce VEGF release in cancer cells, stimulate endothelial cell expression of angiopoietin 2 (Ang2), and inhibit tumor formation (100). The gene discussed is ANGPT2; the disease is cancer.