The antioxidant compound tempol leads to the accumulation of tauro-β-muricholic acid (T-β-MCA) in mice by blocking BSH enzymes in the Lactobacilli; T-β-MCA inhibits FXR signalling, consequently reducing obesity (Li and Chiang, 2014). The gene discussed is NR1H4; the disease is obesity due to melanocortin 4 receptor deficiency.