However, considering the significant efficacy of PD‐1 inhibitors in several cases of locally advanced or recurrent cutaneous squamous cell carcinoma of the ear and temporal region in recent years23, 24, 25, in this particular case, after confirming local uncontrolled disease, the patient received six cycles of carboplatin and 5‐fluorouracil (PF) chemotherapy combined with pembrolizumab immunotherapy, followed by pembrolizumab maintenance therapy. The gene discussed is PDCD1; the disease is cutaneous squamous cell carcinoma.