SMAD4 and cancer: Furthermore, bioinformatic analysis of miR‐34a targets in various cancers identifies numerous target genes such as Jagged 1 (JAG1), CD44, SRY (sex determining region Y)‐box 4 (SOX4), Notch homolog 2 (NOTCH2), Matrix metallopeptidase 9 (MMP9), Interleukin 6 (IL‐6), and SMAD family member 4 (SMAD4) (Soliman et al. 2018; Tang et al. 2015; Ma et al. 2017).