MALAT1 and Alzheimer disease: By comparing our findings with cortical scRNA-seq data from human AD and another mouse model, the Tg2576 model of amyloid-beta pathology, we identify overlapping significant genes across different experimental settings, such as Malat1. Overall, this study provides new insights into the interplay between tauopathy and biological sex at the single-cell level, potentially informing future investigations of sex-specific therapeutic strategies for AD and related tauopathies.