MBP and Alzheimer disease: Similarly, the myelin basic protein encoding gene Mbp showed dominant male-specific changes in oligodendrocytes, with consistent male-specific underexpression in the Tg2576 mouse model and in human AD; however, different patterns were observed in the ThyTau22 model for this gene, with a relative female-specific overexpression at the 7 months time point and significant sex-dimorphic changes at the 17 months time point (overexpression in males, and underexpression in females).