HSP90AB1 and Alzheimer disease: Hsp90ab1, a member of the heat shock protein 90 family with chaperone activity, displayed significant changes in microglia with varying patterns across three datasets: female-specific in 17 months THY-Tau22 (logFC = 2.5, FDR = 8.10E-04), male-specific in human AD data (logFC = 0.3, FDR = 8.25E-05), and sex-neutral in the Tg2576 model (logFCm= -0.22, FDRm=2.47E-07, logFCf= -0.16, FDRf=4.80E-03; Fig. 7a).