PAQR5 and esophageal adenocarcinoma: Recent evidence suggests that PAQR5 functions as a prognostic marker and protective factor in esophageal adenocarcinoma [65], and it plays a significant role in the antitumor activity of progesterone in ovarian and endometrial cancers, where elevated PAQR5 expression correlates with a lower FIGO stage [15, 19].