However, elevated PAQR5 expression may suppress this cytotoxic immune response, as HCC-specific cell cycle-associated kinases can enhance IL-6 production and activate nuclear factor-κB (NF-κB) through zeste homolog 2 (EZH2), leading to an accumulation of polymorphonuclear myeloid-derived suppressor cells (MDSCs) and inhibition of T-cell activity [79]. This evidence concerns the gene PAQR5 and hepatocellular carcinoma.