Instances of such onco-exaptation events include the elevated expression of CSF1R and IRF5 in Hodgkin’s lymphoma [11, 12], the ectopic expression of CALB1 (encoding calbindin) in squamous lung cancer [13], and the creation of an oncogenic form of ALK (anaplastic lymphoma kinase) in melanoma [14]. The gene discussed is CALB1; the disease is melanoma.