HECTD2 and melanoma: For example, HECTD2 drives tumour cell-intrinsic proliferation of melanoma cells, as well as the production of immunosuppressive mediators [91], whereas ectopic expression of CALB1 prevents senescence of squamous lung carcinoma cells, but also prevents pro-tumour recruitment of neutrophils by chemokines that would otherwise be secreted as part of the senescence-associated secretory phenotype [13].