Similarly, ENPP3 promotes cell-intrinsic growth and migration of renal cell carcinoma cells [67, 71], but also regulates the availability of STING ligands for immune cells [70], and given its central role in RNA capping, RNGTT has the potential to affect many other genes with indirect effects on tumour growth. Here, STING1 is linked to hereditary clear cell renal cell carcinoma.