Similarly, ENPP3 promotes cell-intrinsic growth and migration of renal cell carcinoma cells [67, 71], but also regulates the availability of STING ligands for immune cells [70], and given its central role in RNA capping, RNGTT has the potential to affect many other genes with indirect effects on tumour growth. This evidence concerns the gene ENPP3 and hereditary clear cell renal cell carcinoma.