Bullous keratopathy without previous cataract surgery increased from 23 (2.8%) of 817 corneal samples in 1985–1994 to 288 (6.6%) of 4,382 corneal specimens in 2005–2015, while BK after surgery declined from 114 cases (14%) in 1985–1994 to 79 cases (1.8%) in 2005–2015. Here, KNG1 is linked to vesiculobullous skin disease.