These previous findings suggested that the RdB/IL12/GMCSF-RLX- or RdB/IL12/DCN-mediated expression of ECM degrading molecules in the present report may improve the intratumoral distribution of ICIs, while the expression of potent antitumor cytokine IL-12 inflamed poorly immunogenic tumor microenvironment to induce synergistic effect (Fig. 2–4, and 7). This evidence concerns the gene DCN and neoplasm.