CGAS and acute respiratory distress syndrome: Additionally, Brault et al. demonstrated that the cGAS-STING pathway triggers necroptosis in primary macrophages when caspase activity is suppressed, further elucidating the relationship between STING and necroptosis (Brault et al. 2018), In our study, we observed that the release of mtDNA leads to STING activation and necroptosis in septic ARDS.