Furthermore, IFN-α was higher in the LC cohort than in those who have recovered from COVID-19 infection without any persistent clinical symptoms and the LC cohort showed a higher level of I and III IFN up to 8 months together with prolonged activation of plasmacytoid dendritic cells (Phetsouphanh et al., 2022; Queiroz et al., 2024). This evidence concerns the gene IFNA2 and laryngotracheoesophageal cleft.