PSMB8 and central nervous system cancer: A heat map of proteasome-related genes expression from our pre-existing mRNA sequencing dataset of 333 glioma tissues [27–29] demonstrated that the expression level of PSMB8 in WHO grade 4 gliomas was significantly elevated in contrast to that in lower-grade gliomas (WHO grades 2 and 3) (Fig. 2b), which was in line with the outcome of PSMB8 mRNA expression in the GSE16011 cohort (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16011) and REM cohort (https://www.cancerimagingarchive.net/collection/rembrandt/) (Fig. 2c).