Furthermore, KEGG pathway analysis of downregulated genes of Co.sh vs sh-M#2 showed that the genes were enriched within the ECM-receptor interaction, focal adhesion, and the TGF-β signaling pathway (Fig. 5d, Supplementary Table S6), whereas those enriched in ribosome and oxidative phosphorylation were upregulated in PSMB8-knockdown glioma cells (Fig. S4d, Supplementary Table S6). The gene discussed is PSMB8; the disease is glioma.