Both CD45RA−CCR7− effector memory (EM) and CD45RA+CCR7− terminal effector memory (TEM) T cells, which dominate the tumor microenvironment [36], were increased, whereas CD45RA+CCR7+ stem cell-like memory (SCM) and CD45RA−CCR7+ central memory (CM) T cells were reduced (Fig. 1C). This evidence concerns the gene CCR7 and neoplasm.