Although the frequency of MSI-H cases was consistently higher in the presence of pathogenic variants of the MMR gene, the majority of microsatellite statuses retained MSS in most cases with pathogenic variants of the MMR gene, except in colorectal, uterine, and gastric cancers (Fig. 4B, Supplementary Fig. 1, and Supplementary Tables 3, 4). This evidence concerns the gene MRC1 and gastric cancer.