RUNX1 and myeloid leukemia: Other known myeloid leukemia predisposition genes, including DDX41 (P = 3.68e−4, β = 0.115770) and RUNX1 (P = 3.99e−4, β = 0.176099), were identified at a lower significance level than seen for CHEK2 pLoF variants (Fig. 4B).