Similarly, impaired aggresome disintegration upon CB treatment was also observed in non-transformed human ARPE-19 epithelial cells (Fig. 4g–i) as well as in the human A549 lung cancer and murine C2C12 myoblast cell lines (Supplementary Fig. 5c–f), indicating that p97 is generally required for the clearance of endogenous aggresomes in a variety of distinct cell types. Here, VCP is linked to lung cancer.