FLOT1 and head and neck squamous cell carcinoma: To further investigate whether inhibiting FLOT1 expression in radioresistant HNSCC cells modulates radiosensitivity, we exposed an HNSCC cell line to repeated 2 Gy doses of RT over 15 weeks, resulting in the formation of a line that was significantly more radioresistant (CAL27-RR) than the parental cell from which it was derived (CAL27-P) [23].