FLOT1 and head and neck squamous cell carcinoma: Univariate Cox hazard regression revealed that the FLOT1-related gene signature (FLOT1-HR group vs. FLOT1 LR group), sex (male vs. female), HPV status (positive vs. negative), and Clinical T stage (I/II vs. III/IV) were significant prognostic factors for OS in HNSCC (Fig. 3A).