We found significant decreases in BDNF, TrkBTK+ and NURR1 (14–18%) and increases in TrkBTK- and p75 (18–35%) mRNA levels in schizophrenia compared to controls (all p < 0.05), with exacerbation of changes identified in high inflammation schizophrenia. This evidence concerns the gene NR4A2 and schizophrenia.