More specifically, there was a greater mean decrease in BDNF IV (30.8%; p = 0.007), NURR1 (30.1%; p = 0.001) and TrkBTK+ (23.5%; p < 0.001) mRNA levels when comparing high inflammation schizophrenia cases to low inflammation controls than when just examining diagnostic changes alone. This evidence concerns the gene BDNF and schizophrenia.