BDNF and schizophrenia: Hyperdopaminergia is evident in the midbrain in schizophrenia, and since inflammation may interact with BDNF to alter neuron plasticity and function, we hypothesised that BDNF and TrkBTK+ mRNA would be reduced, whilst TrkBTK- mRNA would be increased in the midbrain in schizophrenia, particularly in high inflammation conditions.