While it is possible that increased p75 may be beneficial to oligodendrocytes in schizophrenia midbrain in the absence of neuroinflammation, we speculate that oligodendrocytes may be vulnerable to cell damage/death in high inflammation schizophrenia as mRNA for the cell-death ligand, TNFα, which is known to bind to p75, is also increased in schizophrenia midbrain. Here, TNF is linked to schizophrenia.