NR4A2 and schizophrenia: Gene expression of BDNF IV and its upstream transcription factor, NURR1 was reduced by 18% [F(1110) = 7.591, p = 0.007] and 14.9% [F(1115) = 6.867, p = 0.01] respectively in the schizophrenia group compared to controls (Fig. 1a, b).