Of the 178 MDS with TP53mut VAF < 50%, 37 (20.8%) had 17p loss on karyotype, and the median OS of these cases was comparable to biallelic or presumed biallelic TP53 loss (11.0 vs. 9.9 months; P = 0.63) but significantly poorer than those with monoallelic TP53mut VAF < 50% without 17p loss and/or CK on metaphase cytogenetics (9.9 vs. 33.4 months; P < 0.0001) (Fig. 5C). Here, TP53 is linked to myelodysplastic syndrome.