According to WHO-5 criteria, 155 MDS (25.7%) were classified as MDS-biTP53 as they harbored \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\ge$$\end{document}≥2 TP53mut (n = 115) or 1 TP53mut plus confirmed LOH or cnLOH of the TP53 locus (n = 40). The gene discussed is TP53; the disease is myelodysplastic syndrome.