SIRT6 and Intervertebral disk degeneration: Surprisingly, despite the well-known function of SIRT6 as a histone deacetylase and its role in the regulation of processes linked with intervertebral disc degeneration, including DNA damage, autophagy, senescence, and aging, its role in maintaining disc health remains largely unexplored.15 Accordingly, we, for the first time, report a positive correlation between intervertebral disc health and SIRT6 activity using a mouse model of conditional Sirt6-loss in the disc to address the existing knowledge gaps.