Hyperacetylation of H3K9 in promoters of Runx2, Osx, Dkk1 and Opg in young SIRT6 knockout mice results in low turnover osteopenia by affecting both osteoblastogenesis and bone resorption.57 Moreover, Sirt6 deletion has deleterious effects on articular chondrocytes and shows alterations in proliferating and hypertrophic zones of the growth plate.18,19 Since lineage tracing studies have shown that the AcanCreERT2 allele also targets EP and growth plate cartilages,44 it prompted us to investigate whether deletion of Sirt6 shows any changes in endplate and vertebrae. Here, SIRT6 is linked to Osteopenia.