Interestingly, there was a significant correlation between TGF-β, IL-6, TLR-2, and TLR-4 in the primary CRC tumor and SPP1 expression by macrophages in the metastatic intrahepatic tumor (Fig. 7G and Supplementary Figs. 9F, G). The gene discussed is TLR2; the disease is colorectal carcinoma.