TYK2 and type 1 diabetes mellitus: Next, we employed spatial deconvolution analysis to determine the evolving dynamics of immune regulation in response to TYK2 inhibition in islets, PLNs, and spleen at days 3 and 7 during the evolution of LCMV-induced T1D in the RIP-LCMV-GP mice (Fig. 6n–s and Supplemental Figure S8e–j).