PFKFB2 and familial dilated cardiomyopathy: Notably, mutation in TAX1BP3 has been associated with DCM in a family,65 and PFKFB2 encoding Phosphofructokinase 2, a primary regulator of cardiac glycolysis, has been reported to mitigate hypoxia-related myocardial injury.66 These results suggest that molecular alterations between each state of HF could reveal the underlying process involved in the progression from compensated to uncompensated status leading to HF.