This aligns with recent studies in liver cirrhosis, where ACKR1 and PLVAP double-positive endothelial cells expanded within the fibrotic niche, enhancing leucocyte transmigration.60 Additionally, CCL14, a marker of coronary artery endothelial cells with ACKR1,61 was significantly overexpressed in endothelial cells of fibrotic regions in our spatial transcriptomics (Figure 4C) and immunohistochemistry (see Supplementary data online, Figure S9). This evidence concerns the gene PLVAP and cirrhosis of liver.