As an IGF1 inhibitor involved in inflammation and fibrosis,51 IGFBP2 has been proposed as a diagnostic and prognostic marker for HF.52,53 In our analysis, while natriuretic peptides showed no significant differences between the groups, IGFBP2 exhibited substantial variation, indicating its potential as a novel marker or therapeutic target for fibrosis- and inflammation-driven progression. This evidence concerns the gene IGFBP2 and hydrops fetalis.