The tested variables included tangle density, amyloid load, presence of Lewy bodies in the neocortex, hippocampal sclerosis, cerebral infarcts, cerebral amyloid angiopathy, APOE ε4 allele status, cognition level, slope of cognitive decline, and the slope of cognitive decline adjusted for known Alzheimer's disease and related dementias neuropathologies. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.