The etiology of PD is complex, involving an interplay between genetic, molecular, and environmental factors.2 In PD, α-Synuclein (αSyn) aggregates in inclusions known as Lewy bodies and Lewy neurites, that spread through different brain regions with disease progression.3,4 Progressive changes in cellular and white matter microstructure have also been reported to link with cognitive decline.5 Brain atrophy, including volumetric decreases in dopaminergic areas,6 cortical thinning,7 and gray matter loss,7 also typically occur. The gene discussed is SNCA; the disease is Parkinson disease.