TXNRD1 and neoplasm: Using the Txnrd1flox allele [57] to conditionally delete Txnrd1 only in lung cells exposed to cre recombinase, we generated KrasG12D/+; Nrf2+/+; Txnrd1Δ/Δ (TXNRD1 KO) and KrasG12D/+; Nrf2D29H/+; Txnrd1Δ/Δ (TXNRD1 KO) lung tumors to evaluate the requirement of TXNRD1 for tumor initiation and progression.