TP53 and acute myeloid leukemia: As a shuttling protein, p53 is constantly transported from the nucleus to the cytoplasm and vice versa. In the presence of an AML-related NPM mutant (NPMmut), which is aberrantly localized in the cytoplasm, the cytoplasmic fraction of p53wt significantly increases due to the NPMmut-p53wt interaction [62].