In our study, we had endeavored to exclude participants with potential pre-existing brain pathologies, such as AD, Parkinson’s disease, depression, chronic alcoholism, diabetes, etc. Therefore, despite the significantly elevated blood CRP levels observed in patients with advanced PCa compared with normal elderly males in this study, there were no notable differences in hippocampal biochemical metabolism and cognitive function when compared with the control group. Here, CRP is linked to diabetes mellitus.