IFNG and neoplasm: The hallmarks for PSMB8 functioning were mainly categorized in other immune-related processes, such as antigen processing and presentation, allograft rejection, NK cell mediated cytotoxicity and IFN-γ/α response, etc. These two functional annotation patterns have indicated that PSMB8 may serve as crucial regulator in immune-related processes, especially affecting anti-tumor immunotherapy response.