Among patients with non-communicable diseases, in participants who had diabetes, we found increased age (OR = 1.932; p = 0.012), married (OR = 1.12; p = 0.001), being on insulin therapy (OR = 5.13; p = 0.004), high HbA1c (OR = 6.98; p = 0.001), more years since diagnosis of DM (OR = 4.56; p = 0.001) and presence of one or more diabetes related complications (OR = 5.512; p = 0.001) were strong predictors of having severe depression. The gene discussed is INS; the disease is depressive disorder.