Furthermore, the expression of TP53 also increases in Ovarian (OV), Esophageal (ESCA), Rectal Adenocarcinoma (READ), and HNSCC cancers compared to the other 33 tumours studied (Fig 3C), indicating that TP53 dysregulation is a common feature across multiple cancers. The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.