C1S and diabetes mellitus: Proteins involved in the complement and coagulation cascade were notably upregulated in DM D0 (Fig 6): complement C1S (P < 0.001), complement C7 (P < 0.001), fibrinogen alpha chain (P < 0.001), fibrinogen gamma chain (P < 0.0001), factor III (P < 0.001), factor VII (P < 0.0001), and factor XII (P < 0.0001).