Western blot results showed that IMQ promoted the expression of TLR4, MyD88, p-NF-κB p65 and p-IκBα, while PLE could reduce the protein levels of TLR4, MyD88, p-NF-κB p65 and p-IκB α in the skin of IMQ-induced psoriasis mice (Fig 6A–6D). The gene discussed is NFKB1; the disease is psoriasis.