According to ELISA test findings, the expression of inflammatory cytokines TNF-α and IL-17A in the skin tissue supernatant of mice in the model group exhibited a significant increase compared to the control group, PLE significantly inhibited the release of these inflammatory factors, this result suggests that PLE can improve inflammatory damage in IMQ-induced psoriasis mice (Fig 5A and 5B). The gene discussed is IL17A; the disease is psoriasis.