Specifically, as shown in Fig 3a, C16orf74 was identified as a poor prognostic factor in several cancers, including adrenocortical carcinoma (ACC), colon adenocarcinoma (COAD), glioblastoma (GBM), HNSC, kidney renal clear cell carcinoma (KIRC), lower-grade glioma (LGG), lung adenocarcinoma (LUAD), and pancreatic adenocarcinoma (PAAD). This evidence concerns the gene CLMB and cancer.