STAT3 and urinary bladder carcinoma: In this regard, research indicated that BCP can suppress STAT3 activation via inhibiting its phosphorylation at Tyr705, possibly through interference with upstream kinase JAK2, leading to downregulating STAT3 target genes such as Bcl-2 and cyclin D1 [58], Similarly, it was found that the STAT-3, mTOR, and AKT protein expressions were suppressed by BCP in T24 and 5637 bladder carcinoma cells leading to inhibition of cancer progression and migration [8].