Interestingly, STAT3 was suggested to be an effective player in a complex network organized by BCP that enhanced doxorubicin-sensitivity of cholangiocarcinoma cells and decreased the toxicity in nonmalignant cholangiocytes, thus strengthening the idea of proposing BCP as a dual-acting, chemo-preventive and chemo-sensitizer, BCP as a dual-acting compound, a chemo-preventive and a chemosensitizer [44]. Here, OPN1SW is linked to cholangiocarcinoma.