Interestingly, both systemic lactate (withdrawn from mouse heart) and tumoral lactate (collected by centrifugation of diced tumor tissues) remained at comparably high levels, similar to the saline-treated group, after LOX treatment (Figure 3c), suggesting that the systemic lactate pool is large and even high doses of LOX at sublethal levels are barely able to decrease systemic lactate levels. Here, LOX is linked to neoplasm.