For example, elevated Kla of H3K18 was found in the promoter region of the YTH N6-methyladenosine RNA-binding protein 2 (YTHDF2), which binds to the m6A sites of the tumor suppressor PER1 and TP53 mRNAs for their degradation, and YTHDF2’s enhanced transcriptional expression was associated with the progression and poor prognosis of ocular melanoma [93]. The gene discussed is YTHDF2; the disease is ocular melanoma.