In non-small cell lung cancer (NSCLC) cells, lactate treatment triggered increased Kla in the promoters of the glycolytic enzyme hexokinase 1 (HK-1) and the TCA cycle enzyme isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma (IDH3G), resulting in decreased or increased expression of the metabolic response genes associated with the Kla of HK-1 and IDH3G, respectively [94]. The gene discussed is IDH3A; the disease is non-small cell lung carcinoma.