The effect of XAN, ZER, EUP, and ARZ on apoptosis and cell death was evaluated by staining cancer SH-SY5Y cells with NucView 488 (NV) dye, an enzyme caspase-3 substrate, capable of detecting the activity of caspase-3/7 within cells (early apoptotic cells) [11,12,20], and with propidium iodide (PI), a DNA-binding fluorescent dye (red) able to evidence late apoptotic and necrotic cells [12]. Here, CASP3 is linked to cancer.