ITGB4 and neoplasm: Additionally, laminin encoded by LAMA4, LAMB1, and LAMB2 mediate adhesion through Integrin binding—specifically the Integrin α6β4, composed of integrin α6 (ITGA6) and Integrin β4 (ITGB4)—is suggested to be essential for tumor development and progression, promoting pro-cancer signaling pathways [60].