As a critical glycoprotein, FN1 has not only been confirmed in previous studies to promote metastasis, angiogenesis and proliferation of cancer cells, but also can bind to ITGA5 and ITGB1 to trigger the recruitment and activation of signaling pathway-related proteins, including FAK/Src complex, which exerts a profound impact on tumor progression [33–35]. Here, ITGA5 is linked to cancer.