For example, sauchinone-induced downregulation of epidermal growth factor receptor HER-2 has been evidenced using MCF-7 and Bcap-37 breast cancer cell lines [113], whereas inhibition of the phosphorylation of proteins Akt, ERK, and CREB, coupled to a suppression of the expression of matrix metalloproteinase (MMP)-13, was underlined when using the MDA-MB-231 and MTV/TM-011 breast cancer cell lines [105]. The gene discussed is CREB1; the disease is breast carcinoma.