Returning Rcan1 to the normal two copies by deleting one copy of the gene in Ts65n mice (Ts65n-Rcan1+/−) does not completely restore the B16F10 tumor growth phenotype and microvessel density to wild-type levels, indicating that one or more additional genes on chromosome 21 are involved in the tumor growth suppression. Here, RCAN1 is linked to neoplasm.