SHBG and cancer: Therefore, we systematically summarized and quantified the available evidence on the sex-specific associations of endogenous sex steroid hormones, including TT, bioavailable testosterone (BT), free testosterone (FT), DHEAS, E2, and dehydroepiandrosterone (DHEA), as well as SHBG, with risk of all-cause and cause-specific mortality, including CVD, cancer, and other causes in the general population.