On the other hand, the HC cohort showed a significantly higher spike-induced IFN-γ level [154.4 (67.3–345)] than SLE patients [66.7 (20.1–219.4)] (p = 0.01), while no differences were found between the two therapy groups (Table 2 and Figure 1A). Here, IFNG is linked to systemic lupus erythematosus.