CD8A and neoplasm: In Tu’s study, vaccines incorporating polysaccharide adjuvants from Crocus sativus petals immuno-edited the tumor microenvironment by promoting recruitment of immune cells, such as NK cells and CD8+T cells, while reducing immune suppressor cells, including MDSCs, TAMs, and Tregs along with their regulators; furthermore, it induced a shift from an M2-TAMs phenotype towards an M1 phenotype within tumor tissues.