Temizoz et al. co-activated the TLR9 and STING signaling pathways via the synergistic effects of their agonists K3CpG and cGAMP, and the immunization showed significant antitumor effects against B16-F10 melanoma and EG-7 lymphoma and maintained a 100% survival rate for mice with lethal pancreatic cancer [171,172]. This evidence concerns the gene STING1 and melanoma.