The humoral immunity of triatomines includes many antimicrobial peptides induced by the Toll, IMD (immunodeficiency), JAK/STAT (Janus kinase/signal transducer and activator of transcription), JNK (Jun-N-terminal kinase), and MAPK (mitogen-activated protein kinase) signaling pathways [81,82,86,87,88,89,90]. Here, MAPK8 is linked to Immunodeficiency.