Furthermore, dendritic cell-derived exosomes (DEX) that are coated with peptides targeting HCC (P47-P), epitopes of alpha-fetoprotein (AFP212-A2), and domains of high-mobility group nucleosome-binding protein 1 (N1ND-N) function as immune adjuvants, eliciting specific immune responses against tumors in HCC via exosome-anchored peptides [100]. This evidence concerns the gene AFP and hepatocellular carcinoma.