(3) Results: NAC immunotherapy led to a significant reduction in bacterial loads both in THP-1 cells and murine infection models, which was associated with enhanced antioxidant effects and downregulation of apoptosis signal-regulating kinase 1 (ASK1)–mitogen-activated protein ki-nase/extracellular signal-regulated kinase 3/6 (MKK3/6)–p38 mitogen-activated protein kinase (MAPK)-mediated inflammatory immune responses. This evidence concerns the gene MAPK14 and infection.