APOE and Alzheimer disease: Extant studies are among overwhelmingly White populations, excluding members of racial minority groups, who have been estimated to have a higher risk for and the steepest increase in incident ADRD in the next 40 years,25,26 as well as a higher frequency of the APOE4 allele due to genetic inheritance and ancestry.27 Furthermore, many blood-based biomarker studies recruited human participants solely from clinical settings, often with very different demographics and AD risk than real-world, community-dwelling older adults.